New work from postdoctoral fellows Nouhou Haidara (left) and Carlo Yague-Sanz (not on picture) as well as graduate student Cédric Boulanger (right on picture) now report that the primary role of phosphorylation of serine 2 on the Carboxy-Terminal domain (CTD) of RNA polymerase II is to repress cryptic antisense transcription, and not to promote mRNA 3′ end processing and transcription termination.