Our Publications

The quality of the research findings published by our laboratory over the past 15 years is reflected by the breadth and multidisciplinary nature of our studies. Accordingly, the capacity to publish studies in top-ranked journals such as Molecular Cell, Genes & Development, Nature Structural & Molecular Biology, Cell Reports, PLoS Genetics, and Nature Communications is a clear indication of the exceptional significance of our findings and depth of our research contributions.
May 2024

Repression of pervasive antisense transcription is the primary role of fission yeast RNA polymerase II CTD Serine 2 phosphorylation

Boulanger, C., Haidara, N., Yague-Sanz, C., Larochelle, M., Jacques, P-É., Hermand, D., and F. Bachand. (2024). Nucleic Acids Research, In press. http://10.1093/nar/gkae436

June 2023

Chromatin remodeling by Pol II primes efficient Pol III transcription

Yague-Sanz, C., Midget, V., Larochelle, M., Bachand, F., Wéri, M., Morillon, A., and D. Hermand. (2023). Nature Communications 14, 3587. https://www.nature.com/articles/s41467-023-39387-4

May 2023

The conserved RNA-binding protein Seb1 promotes cotranscriptional ribosomal RNA processing by controlling RNA polymerase I progression

Duval, M., Yague-Sanz, C., Turowski, T.W., Petfalski, E., Tollervey, D., and F. Bachand (2023). Nature Communications 14, 3013. https://rdcu.be/dcX39

May 2023

Ribosomal Protein uS5 and Friends: Protein–Protein Interactions Involved in Ribosome Assembly and Beyond

Landry-Voyer, A.M., Mir Hassani, Z., Avino, M. and F. Bachand (2023). Biomolecules, 13: 853. https://pubmed.ncbi.nlm.nih.gov/36754576/

March 2023

PABPN1 prevents the nuclear export of an unspliced RNA with a constitutive transport element and controls human gene expression via intron retention

Kwiatek, L., Landry-Voyer, A.M., Latour, M., Yague-Sanz, C., and F. Bachand (2023). RNA Journal, 29: 644-662. https://pubmed.ncbi.nlm.nih.gov/36754576/

October 2021

Fission yeast proteins Puf2 and Puf4 are involved in repression of frp1 expression in response to iron

Beadoin, J., Normant, V., Brault, A., Henry, DJ., Bachand, F., Massé, E., Chua, G., and S. Labbé (2021). Molecular Microbiology 116: 1361-1377. https://pubmed.ncbi.nlm.nih.gov/34614242/

July 2021

Co-transcriptional RNA cleavage by Drosha homolog Pac1 triggers transcription termination in fission yeast

Yague-Sanz, C., M. Duval, M. Larochelle, and F. Bachand (2021). Nucleic Acids Res 49:8610-8624. https://pubmed.ncbi.nlm.nih.gov/34352089/

December 2020

PDCD2 functions as an evolutionarily conserved chaperone dedicated for the 40S ribosomal protein uS5 (RPS2)

Landry-Voyer, A. M., D. Bergeron, C. Yague-Sanz, B. Baker and F. Bachand (2020). Nucleic Acids Res, 48:12900-12916. https://pubmed.ncbi.nlm.nih.gov/33245768/

July 2020

Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation

Yague-Sanz, C., Y. Vanrobaeys, R. Fernandez, M. Duval, M. Larochelle, J. Beaudoin, J. Berro, S. Labbe, P. E. Jacques and F. Bachand (2020). Genes Dev 34: 883-897. https://www.ncbi.nlm.nih.gov/pubmed/32499400

August 2019

Senataxin homologue Sen1 is required for efficient termination of RNA polymerase III transcription.

Rivosecchi, J., M. Larochelle, C. Teste, F. Grenier, A. Malapert, E. P. Ricci, P. Bernard, F. Bachand and V. Vanoosthuyse (2019). EMBO J 38: e101955. https://www.ncbi.nlm.nih.gov/pubmed/31294478

March 2019

Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast.

Larochelle, M., D. Bergeron, B. Arcand and F. Bachand (2019). J Cell Sci 132. https://www.ncbi.nlm.nih.gov/pubmed/31064814

February 2019

The 40S ribosomal protein uS5 (RPS2) assembles into an extra-ribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction.

Dionne, K. L., D. Bergeron, A. M. Landry-Voyer and F. Bachand (2019). J Biol Chem 294: 1944-1955. https://www.ncbi.nlm.nih.gov/pubmed/30530495

November 2018

Proteomic profiling and functional characterization of post-translational modifications of the fission yeast RNA exosome

Telekawa, C., F. M. Boisvert and F. Bachand (2018). Nucleic Acids Res 46: 11169-11183. https://www.ncbi.nlm.nih.gov/pubmed/30321377

October 2018

Common mechanism of transcription termination at coding and noncoding RNA genes in fission yeast

Larochelle, M., M. A. Robert, J. N. Hebert, X. Liu, D. Matteau, S. Rodrigue, B. Tian, P. E. Jacques and F. Bachand (2018). Nat Commun 9: 4364. https://www.ncbi.nlm.nih.gov/pubmed/30341288

September 2018

Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast

Atkinson, S. R., S. Marguerat, D. A. Bitton, M. Rodriguez-Lopez, C. Rallis, J. F. Lemay, C. Cotobal, M. Malecki, P. Smialowski, J. Mata, P. Korber, F. Bachand and J. Bahler (2018). RNA 24: 1195-1213. https://www.ncbi.nlm.nih.gov/pubmed/29914874

October 2017

Comparative analysis of alternative polyadenylation in S. cerevisiae and S. pombe

Liu, X., M. Hoque, M. Larochelle, J. F. Lemay, N. Yurko, J. L. Manley, F. Bachand and B. Tian (2017). Genome Res 27: 1685-1695. http://www.ncbi.nlm.nih.gov/pubmed/28916539

May 2017

Polyadenylation site selection: linking transcription and RNA processing via a conserved carboxy-terminal domain (CTD)-interacting protein

Larochelle, M., J. Hunyadkurti and F. Bachand (2017). Curr Genet 63: 195-199. http://www.ncbi.nlm.nih.gov/pubmed/27582274

February 2017

Multiple Transcriptional and Post-transcriptional Pathways Collaborate to Control Sense and Antisense RNAs of Tf2 Retroelements in Fission Yeast.

Mallet, P. L., M. Larochelle and F. Bachand (2017). Genetics 205: 621-632. https://www.ncbi.nlm.nih.gov/pubmed/28007890

November 2016

Human PDCD2L Is an Export Substrate of CRM1 That Associates with 40S Ribosomal Subunit Precursors

Landry-Voyer, A. M., S. Bilodeau, D. Bergeron, K. L. Dionne, S. A. Port, C. Rouleau, F. M. Boisvert, R. H. Kehlenbach and F. Bachand (2016).  Mol Cell Biol 36: 3019-3032. http://www.ncbi.nlm.nih.gov/pubmed/27697862

July 2016

The Nrd1-like protein Seb1 coordinates cotranscriptional 3' end processing and polyadenylation site selectio

Lemay, J. F., S. Marguerat, M. Larochelle, X. Liu, R. van Nues, J. Hunyadkurti, M. Hoque, B. Tian, S. Granneman, J. Bahler and F. Bachand (2016). Genes Dev 30: 1558-1572. http://www.ncbi.nlm.nih.gov/pubmed/27401558

December 2015

A Polyadenylation-Dependent 3' End Maturation Pathway Is Required for the Synthesis of the Human Telomerase RNA

Nguyen, D., V. Grenier St-Sauveur, D. Bergeron, F. Dupuis-Sandoval, M. S. Scott and F. Bachand (2015). Cell Rep 13: 2244-2257. http://www.ncbi.nlm.nih.gov/pubmed/26628368

December 2015

Fail-safe transcription termination: Because one is never enough

Lemay, J. F. and F. Bachand (2015). RNA Biol 12: 927-932. https://www.ncbi.nlm.nih.gov/pubmed/26273910

July 2015

Regulated Intron Retention and Nuclear Pre-mRNA Decay Contribute to PABPN1 Autoregulation

Bergeron, D., G. Pal, Y. B. Beaulieu, B. Chabot and F. Bachand (2015). Mol Cell Biol 35: 2503-2517. http://www.ncbi.nlm.nih.gov/pubmed/25963658

June 2015

Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yea

Bitton, D. A., S. R. Atkinson, C. Rallis, G. C. Smith, D. A. Ellis, Y. Y. Chen, M. Malecki, S. Codlin, J. F. Lemay, C. Cotobal, F. Bachand, S. Marguerat, J. Mata and J. Bahler (2015). Genome Res 25: 884-896. http://www.ncbi.nlm.nih.gov/pubmed/25883323

October 2014

The RNA exosome promotes transcription termination of backtracked RNA polymerase II

Lemay, J. F., M. Larochelle, S. Marguerat, S. Atkinson, J. Bahler and F. Bachand (2014). Nat Struct Mol Biol 21: 919-926. http://www.ncbi.nlm.nih.gov/pubmed/25240800

December 2013

Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay

Grenier St-Sauveur, V., S. Soucek, A. H. Corbett and F. Bachand (2013). Mol Cell Biol 33: 4718-4731. http://www.ncbi.nlm.nih.gov/pubmed/24081329

March 2013

A proline-tyrosine nuclear localization signal (PY-NLS) is required for the nuclear import of fission yeast PAB2, but not of human PABPN1

Mallet, P. L. and F. Bachand (2013). Traffic 14: 282-294. http://www.ncbi.nlm.nih.gov/pubmed/23279110

November 2012

The THO complex cooperates with the nuclear RNA surveillance machinery to control small nucleolar RNA expression

Larochelle, M., J. F. Lemay and F. Bachand (2012). Nucleic Acids Res 40: 10240-10253. http://www.ncbi.nlm.nih.gov/pubmed/22965128

November 2012

Polyadenylation-dependent control of long noncoding RNA expression by the poly(A)-binding protein nuclear 1

Beaulieu, Y. B., C. L. Kleinman, A. M. Landry-Voyer, J. Majewski and F. Bachand (2012). PLoS Genet 8: e1003078. http://www.ncbi.nlm.nih.gov/pubmed/23166521

June 2011

A Pre-mRNA degradation pathway that selectively targets intron-containing genes requires the nuclear poly(A)-binding protein

Lemieux, C., S. Marguerat, J. Lafontaine, N. Barbezier, J. Bahler and F. Bachand (2011). Mol Cell 44: 108-119. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=21981922

September 2010

Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast

St-Andre, O., C. Lemieux, A. Perreault, D. H. Lackner, J. Bahler and F. Bachand (2010). J Biol Chem 285: 27859-27868. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20622014

May-June 2010

Negative regulation of meiotic gene expression by the nuclear poly(a)-binding protein in fission yeast

Lemay, J. F., C. Lemieux, O. St-Andre and F. Bachand (2010). RNA Biol 7: 291-295. http://www.ncbi.nlm.nih.gov/pubmed/20400847

January 2010

The nuclear poly(A)-binding protein interacts with the exosome to promote synthesis of noncoding small nucleolar RNAs

Lemay, J. F., A. D’Amours, C. Lemieux, D. H. Lackner, V. G. St-Sauveur, J. Bahler and F. Bachand (2010). Mol Cell 37: 34-45. https://www.ncbi.nlm.nih.gov/pubmed/20129053